3-Hydroxy-Propanamine Derived Neuronal Reuptake Inhibitors
Patent Information:
Filing Country: USA
Application No: 08/889357
Filing Date: 08 July 1997
Patent No: 6069177
Issue Date: 30 May 2000
 
Inventors:
Inventor 1: Prof. Paul Robert, CARLIER
Inventor 2: Ms. Ching Kam, LO
Inventor 3: Mr. Man Chu, LO
Inventor 4: . Elliott, RICHELSON

Technology
Antidepressants such as Prozac, Paxil and Zoloft, are characterized by an ability to selectively block reuptake of serotonin (5-HT). Selective NE-reuptake inhibitor antidepressants such as Tomoxetine and Vivalan have also been developed. Effexor and Serzone have been termed SNRI antidepressants because they inhibit 5-HT and NE reuptake with similar potency. However, these present drugs are ineffective to some patients. Only new generation of drugs possess reuptake inhibition profile different from those currently known can solve the problem. The invention relates to the new class of antidepressant compounds, which exhibit synaptosomal reuptake inhibition of neurotransmitters such as serotonin (5-HT), norephinephrine (NE), and dopamin (DA) simultaneously. These new compounds possess special reuptake inhibition profile. The antidepressant properties of these compounds were assayed. The best of these new compounds bind to the transporter protein 175 times stronger than serotonin itself. These compounds will therefore effectively block synaptosomal reuptake of serotonin.
 
 
Potential Application   Advantage
- New antidepressant drugs   1. Comparatively reduced therapeutic dosages of antidepressant compounds
2. Less side effects
3. More effective
4. Wide range of usage
     
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香港九龍清水灣 香港科技大學
THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY, CLEAR WATER BAY, KOWLOON