Enediyne Derivatives
Patent Information:
Filing Country: USA
Application No: 09/621517
Filing Date: 21 July 2000
Patent No: 6391916
Issue Date: 21 May 2002
 
Inventors:
Inventor 1: Prof. Wei-Min, DAI
Inventor 2: Mr. Wataru, HAMAGUCHI
Inventor 3: Mr. Atsushi, ISHII
Inventor 4: Dr. Yuk Ha, LEE
Inventor 5: Prof. Sei-ichi, NISHIMOTO
Inventor 6: Dr. Anxin, WU
Inventor 7: Prof. Ling, ZHOU

Technology
A novel class of synthetic substances that exhibits DNA cleavage and anticancer activity is discovered. Enediyne is a well-known anticancer agent. Mechanistic study on the new invention confirms that these synthetic substances are converted into enediynes under physiological condition and then deliver enediyne-like biological activity. Compared with enediyne, these substances possess higher chemical stability at room temperature and can therefore be used as enediyne prodrugs. Several synthetic processes were developed for these substances and their DNA cleavage capability and their cytotoxicity against cancer cell lines were evaluated. The results confirm that the substances are of potential value for developing into novel anticancer agents.
 
 
Potential Application   Advantage
- A potential replacement of the anticancer drug enediyne   1. Heat-liable
2. Chemically stable at room temperature
3. Easy to be handled
     
Patent documents are available at [http://patentsearch2.ttc.ust.hk/ListPatents.asp], and can be viewed by inserting patent no., application no. or TTC code <TTC Code> into the corresponding field.
Contact information :
Ms Shirley Woo
(852) 2358 7918
cawoosw@ust.hk
HKUST R and D Corporation Ltd
http://rdc.ust.hk
(852) 2358 7917
ttcac@ust.hk
Technology Transfer Center
http://www.ttc.ust.hk/
   
香港九龍清水灣 香港科技大學
THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY, CLEAR WATER BAY, KOWLOON