Antisense Oligonucleotides Targeted to Human CDC45
Patent Information:
Filing Country: USA
Application No: 10/232923
Filing Date: 29 August 2002
Patent No: 7393950
Issue Date: 01 July 2008
 
Inventors:
Inventor 1: Dr. Daorong, FENG
Inventor 2: Prof. Chun, LIANG
Inventor 3: Dr. Zhiling, YU

Technology
Antisense oligonucleotides that inhibit expression of human replication-initiation protein as well as methods of preventing or treating hyperproliferative conditions using said oligonucleotides are introduced. One aspect provides an antisense oligonucleotides that inhibits the expression of human replication-initiation protein and has a sequence complementary to at least a portion of a target sequence encoding a human replication initiation gene. By administering a therapeutically effective amount of antisense oligonucleotides or by contacting the hyperproliferating cells with an effective amount of antisense oligonucleotides, expression of replication-initiation protein is inhibited. Methods of screening and testing active antisense oligonucleotides for their ability to inhibit gene expression are also introduced.
 
 
Potential Application   Advantage
- Clinical trials for the development of new effective anticancer drugs
- Useful for the development of antisense oligonucleotides as medicine
  1. Inhibition of DNA replication thus cancer cells growth can be inhibited and can be killed
2. Have little side effect
3. Without inhibiting the metabolism and functions of non-dividing normal cells
4. Comprehensive
5. Relatively low cost
6. Efficient
     
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Contact information :
Ms Shirley Woo
(852) 2358 7918
cawoosw@ust.hk
HKUST R and D Corporation Ltd
http://rdc.ust.hk
(852) 2358 7917
ttcac@ust.hk
Technology Transfer Center
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香港九龍清水灣 香港科技大學
THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY, CLEAR WATER BAY, KOWLOON