Use of Marine Fungus Originated Compounds as Antifouling Agents
Patent Information:
Filing Country: USA
Application No: 11/303610
Filing Date: 16 December 2005
Patent No: 8257478
Issue Date: 04 September 2012
Inventor 1: Prof. Peiyuan, QIAN
Inventor 2: Dr. Xiancui, LI
Inventor 3: Dr. Fuk Ning, KWONG
Inventor 4: Ms. Lai Hung, YANG
Inventor 5: Dr. Serguei Vladimirovich, DOBRETSOV

Although experimentation on antifouling technologies for shipping has continued for approximately 100 years, metal containing antifouling paints continue to be widely adopted. These paints are usually copper or tin based compounds like tributyl tin (TBT) that can prevent fouling by continuously releasing the copper or tin into the surrounding seawater. However, these compounds have negative effects on the marine environment. The present invention concerns alternative antifouling agents derived from marine microbes. It is based on the discovery that 3 strains of marine fungi and a deep-sea bacterium produce small molecular organic compounds that have antibacterial activity as well as inhibitory activity on larval attachment and metamorphosis of barnacle and polychaete. On contrary to majority of the currently employed biocides, the antifouling effect of these new compounds is of low-toxicity and bio-degradability. Unlike other natural products with antifouling properties derived from marine organisms, the present microbial secondary metabolites can be generated biotechnologically in large scale utilizing commercially available fermenting technology. This new invention does not require the maintenance of a marine culture for large-scale production of antifouling agents, thus resolving manufacturing problems with geographical restrictions.
Potential Application   Advantage
- Antifouling paints and coating for seawater pipeline, cables, fish nets/cages, apparatus for navigation
in sea, etc.
- Antibiotics for marine disease control
  1. Lower toxicity
2. Antifouling agents and antibiotics are bio-degradable
3. Production can be easily performed on land-based fermenters in large scale
4. Lower manpower requirements
5. Lower production cost
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